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22 May 2000

Drug for post-menopausal women with advanced breast cancer

Post-menopausal women with advanced breast cancer, known to be sensitive to hormonal treatments, can now be offered a drug that is superior to the most commonly used first line treatment. New data from clinical trials, presented at the annual meeting of the American Society of Clinical Oncology in New Orleans (ASCO) indicates that, in this group of patients, treatment with a selective aromatase inhibitor delays progression of their cancer for longer than in those receiving the current gold standard treatment.

Post-menopausal women with advanced breast cancer, known to be sensitive to hormonal treatments, can now be offered a drug that is superior to the most commonly used first line treatment. New data from clinical trials, presented at the annual meeting of the American Society of Clinical Oncology in New Orleans (ASCO) indicates that, in this group of patients, treatment with a selective aromatase inhibitor delays progression of their cancer for longer than in those receiving the current gold standard treatment.

The response of breast cancer tumours to the aromatase inhibitor is at least as good as the current standard treatment. In addition, in patients whose cancer is likely to respond to hormonal treatment the time to progression of disease is longer in patients receiving the aromatase inhibitor, than those receiving standard treatment. The aromatase inhibitor is well tolerated, with a comparable side-effect profile to the gold standard treatment.

The new results show that using this aromatase inhibitor may provide patients and clinicians with an important alternative to the most widely used treatment for advanced breast cancer in post-menopausal women.

About 1 in 12 women develop breast cancer at some time during their life and more than 1000 women die of the disease each month in the UK .

Dr Adrian Harnett, Consultant Oncologist at the Beatson Oncology Centre Glasgow commented that " For the past few decades there has been only one treatment of choice for hormone-sensitive advanced breast cancer in postmenopausal women. New results from clinical trials now show that there may be an alternative drug which provides longer disease control in these patients".

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Further enquiries to:

Lyndsey Conway
AstraZeneca
Horizon Place
Luton
01582
faPRCommunicationsDept-GB-AstraPharmaceuticalsLtd@astrazeneca.com

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